Down's syndrome with transient myeloproliferative disorder.

Children with Down's syndrome are at an increased risk for development of several hematological disorders like acute leukemia, acute myelofibrosis of childhood and transient myeloproliferative disorder (TMD)(1). Transient myeloproliferative disorder is recognized shortly after birth or in neonatal period and is characterized by leukocytosis and thrombocytopenia, which resolves spontaneously in few weeks to months(2). Transient myeloproliferative disorder is an uncommon syndrome strongly associated with abnormalities of chromosome 21(3). To the best of our knowledge this entity has not been described in the Indian literature. Here we report our experience of one such case.